All, It is obviously a good idea to sterilize disinfectants going into a cleanroom environment, but for the life of me I cannot remember if I have read this as a requirement or a suggestion in any regulatory document (aside from posted 483s). Two questions: 1. Is this a written in any guidance document? 2. What are some good references on contamination of disinfecting solutions relevant to this topic? Thanks for the help. Scott ------------------ The PMFList (http://microbiol.org/PMFList_info.htm) is operated from The Microbiology Network (http://microbiol.org) and supported by our sponsors (http://microbiol.org/sponsor.htm) as a service to the scientific community. Please take a second to visit our sponsors' web sites and say thank you for their support of this service. AAI - http://www.aaiintl.com/Micro.htm Accugenix - http://www.accugenix.com/ Becton Dickinson Microbiology Systems - http://www.bd.com/industrial Chemunex - http://www.chemunex.com/ Microcheck - http://www.microcheck.com/ MIDI - http://www.midi-inc.com/ MIDI Microbial ID - http://www.microbialid.com/ MIDI Labs - http://www.midilabs.com/ Millipore - http://www.millipore.com/