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Subject:
From:
Tony Cundell <[log in to unmask]>
Reply To:
The Pharmaceutical Microbiology Forum Email List <[log in to unmask]>
Date:
Mon, 3 Feb 2020 21:22:27 -0500
Content-Type:
text/plain
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Urease would hydrolyze urea to ammonia which is more toxic.

On Mon, Feb 3, 2020, 5:57 PM Caron Weidman <[log in to unmask]> wrote:

> Don,
> We did consider this and we have ordered catalase. We also ordered urease
> because the urea will also need to be neutralized, will it not?
>
> ________________________________
> From: The Pharmaceutical Microbiology Forum Email List <
> [log in to unmask]> on behalf of Donald English <
> [log in to unmask]>
> Sent: Monday, February 3, 2020 3:11 PM
> To: [log in to unmask] <
> [log in to unmask]>
> Subject: Re: [PMFLIST] neutralizing carbamide peroxide
>
> Dear Carol,
>
> It is my understanding that Carbamide peroxide is urea hydrogen peroxide.
> According to the MSDS for this material, it is a crystalline solid that is
> easy soluble in cold water.  You do not need IPM to dissolve it if it is
> incorporated into a product formulation.  To neutralize the antimicrobial
> activity of this raw ingredient that is present in a product formulation, I
> would recommend the usage of Catalase.  I have seen people use a 0.01%
> Catalase solution to neutralize hydrogen peroxide.  Depending upon your
> suitability test results, you may need to increase the concentration of
> Catalase in your diluent to neutralize hydrogen peroxide concentration that
> is present in your formulation.  You also need to remember that a Catalase
> diluent cannot be sterilized by using an autoclave because heat will
> destroy the enzyme.  A stock solution of Catalase will need to be filter
> sterilized and a sterile aliquot will need to be added to the diluent.
>
> Regards,
> Don
>
> Donald J. English Microbiological Quality Consulting LLC
> Florham Park, New Jersey 07932
>
>
> On Mon, Feb 3, 2020 at 12:43 PM Timothy Cser <
> [log in to unmask]> wrote:
>
> > Hi Caron.  If it is insoluble in water, I would use warm IPM then fluid K
> > rinse, and fluid A as final rinse.
> >
> > If you'd like more information, please contact me directly.
> > [log in to unmask]
> >
> > Sincerely,
> >
> > Tim Cser
> > MilliporeSigma
> >
> > -----Original Message-----
> > From: The Pharmaceutical Microbiology Forum Email List <
> > [log in to unmask]> On Behalf Of Caron Weidman
> > Sent: Tuesday, January 28, 2020 8:24 AM
> > To: [log in to unmask]
> > Subject: [PMFLIST] neutralizing carbamide peroxide
> >
> > Hello,
> > Wondering if anyone has a method to neutralize carbamide peroxide? We
> have
> > a formula using this compound at 7.2% and need to neutralize for
> > suitability testing purposes.
> >
> > Kind Regards,
> >
> > Caron Weidman | Microbiology Lab Manager Elba Laboratories | 1925 W.
> Maple
> > Rd. | Troy, MI 48084
> > Phone: 248.288.6098 |
> >
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> The PMFList (http://microbiologynetwork.com/pmflist.asp) is operated from
> The Microbiology Network (http://microbiologynetwork.com) and supported by
> our sponsors as a service to the scientific community.
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>
>
> Steris - http://www.sterislifesciences.com/
>
> Charles River Laboratories - http://www.criver.com/
>
> Veltek Associates, Inc - http://www.sterile.com
>
> Microbiologics, Inc. - http://www.microbiologics.com
>
> BD Industrial Media - http://www.bd.com/ds/
>
> Boston Analytical http://www.bostonanalytical.com/
>
> Associates of Cape Cod, Inc. - http://www.acciusa.com/
>
>
> =================================
> The nature of this service is to provide a medium for communication.  The
> specific statements and endorsements of individuals participating in the
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> the PMF, or the sponsors of the list.
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> The Microbiology Network (http://microbiologynetwork.com) and supported by
> our sponsors as a service to the scientific community.
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> Please take a second to visit our sponsors' web sites and say thank you
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>
>
> Steris - http://www.sterislifesciences.com/
>
> Charles River Laboratories - http://www.criver.com/
>
> Veltek Associates, Inc - http://www.sterile.com
>
> Microbiologics, Inc. - http://www.microbiologics.com
>
> BD Industrial Media - http://www.bd.com/ds/
>
> Boston Analytical http://www.bostonanalytical.com/
>
> Associates of Cape Cod, Inc. - http://www.acciusa.com/
>
>
> =================================
> The nature of this service is to provide a medium for communication.  The
> specific statements and endorsements of individuals participating in the
> discussions are not necessarily those of The Microbiology Network, Inc.,
> the PMF, or the sponsors of the list.
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The PMFList (http://microbiologynetwork.com/pmflist.asp) is operated from
The Microbiology Network (http://microbiologynetwork.com) and supported by
our sponsors as a service to the scientific community.

Please take a second to visit our sponsors' web sites and say thank you for their support of this service.
If your company would be interested in sponsoring this community, please contact [log in to unmask]



Steris - http://www.sterislifesciences.com/

Charles River Laboratories - http://www.criver.com/

Veltek Associates, Inc - http://www.sterile.com

Microbiologics, Inc. - http://www.microbiologics.com

BD Industrial Media - http://www.bd.com/ds/

Boston Analytical http://www.bostonanalytical.com/

Associates of Cape Cod, Inc. - http://www.acciusa.com/


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The nature of this service is to provide a medium for communication.  The specific statements and endorsements of individuals participating in the discussions are not necessarily those of The Microbiology Network, Inc., the PMF, or the sponsors of the list.

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