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July 1999

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The Pharmaceutical Microbiology Mail List <[log in to unmask]>
Date:
Thu, 8 Jul 1999 13:40:36 -0500
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This is why most people (a) use cleaner/DISINFECTANTS in cleanrooms, (b) FILTER
the agents thru 0.2 micron filters before use, and (c) use sterile, disposable
mop-heads.
        NO, there should be no coliforms or E. coli in your cleaners-- there
should NEVER be ANY organisms at ANY level in ANYTHING introduced into a
cleanroom.
        M.Carroll ([log in to unmask])

______________________________ Reply Separator _________________________________
Subject: [PMFLIST] Microbial limits for cleaning agents used in clean
Author:  <[log in to unmask]> at INTERNET-MAIL
Date:    7/8/99 1:15 PM


Hi all,

I would like to know if the only applicable limits for cleaning agents to use in
cleanrooms are OSHA ones.
Our supplier gave me this limits for the concentrate detergent (non ionic,
without disinfectant)

                          R.S.P < 1,0 x 10 4 u.f.c./ml
                          E. coli < 10 u.f.c./ ml
                          Coliforms < 10 u.f.c./ml

I think this limits are too high if you compare them with those for purified
water used in the preparation of cleaning solutions (< 100 u.f.c./ml). What`s
your opinion? Is it not possible to manufacture detergents with a lower level of
contamination? Why are E.coli and coliforms allowed?
Are the limits above OSHA ones? (I`m sorry I haven`t OSHA requirements)
Thanks in advance, all your comments are welcome.

Laura Acevedo
[log in to unmask]


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