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May 2001

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Subject:
From:
Clare MacLeod <[log in to unmask]>
Reply To:
The Pharmaceutical Microbiology Mail List <[log in to unmask]>
Date:
Tue, 1 May 2001 06:48:33 +0200
Content-Type:
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A course called Pharmaceutical Microbiology" by David Begg Associates with
the University of
Strathclyde has a chapter or two on disinfectants.  One of the chapters
contains a section on the Validation of Disinfectants and Disinfectant
Procedures.  In this section there are user friendly directions on how to
validate your disinfectants using Membrane filtration for laboratory
dilution studies and Laboratory surface studies as well as plant based
studies to determine the effectiveness of disinfectant practices.

As the chapter reads be pragmatic with your disinfectant procedures and
validation -  these studies will allow for the determination of
antimicrobial efficacy against bacterial cultures,  activity of
disinfectants on various surfaces as well as the assessment of
antimicrobial effect of the disinfectant and routine cleaning procedures
used.

I have never used the phenol method myself - but did research the method
and found the method to be lengthy and out of date (i.e microbiologists
should surely be able to come up with a more practical simple method).  The
above methods are simple and practical which is what the end users of
disinfectants require - i.e. how effective is the disinfectant in a real
situation i.e. disinfectant vs micro organism.

Thanx Clare MacLeod
Bodene Microbiology Laboratory



                    Anthony
                    Cundell               To:     [log in to unmask]
                    <[log in to unmask]        cc:
                    WYETH.COM>            Subject:     [PMFLIST] Alternate to the
                    Sent by: The          Phenol Resistance Test
                    Pharmaceutical
                    Microbiology
                    Mail List
                    <PMFLIST@MICRO
                    BIOL.ORG>


                    04/30/01 10:53
                    PM
                    Please respond
                    to The
                    Pharmaceutical
                    Microbiology
                    Mail List






The EPA is actively reviewing the elimination or modification of the Phenol
Resistance Test as a requirement for the registration of disinfectants.

The purpose of the test is control or verify the resistance of test
organisms.

The USP attempted to add such as test to the Antimicrobial Effectiveness
test as a method of controlling the inherent variability of the test.

Does anyone have an opinion as to the direction we should go with this
issue?

Tony Cundell
Wyeth-Ayerst Pharmaceuticals


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