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December 2003

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Subject:
From:
Richard Prince <[log in to unmask]>
Reply To:
The Pharmaceutical Microbiology Forum Email List <[log in to unmask]>
Date:
Fri, 5 Dec 2003 16:11:37 -0500
Content-Type:
text/plain
Parts/Attachments:
text/plain (172 lines)
David,

I support Art's statement.

Richard Prince
[log in to unmask]
----- Original Message -----
From: "Art Vellutato, Jr." <[log in to unmask]>
To: <[log in to unmask]>
Sent: Friday, December 05, 2003 2:46 PM
Subject: Re: [PMFLIST] Resistant Organisms as a Result of Disinfectant / S
poricidal Agen ts


> David,
>
> There is no conclusive data published in the industry at levels noticed in
> controlled environments and to support that an organism may become
> resistant to a disinfecting agent. It is theoretical and should be
excluded
> from consideration. In fact, most regulatory agencies have not included in
> their documentation or recommendations that two disinfectant should be
> rotated to combat the possible building of a resistance to one or the
> other.  This includes the new FDA Aseptic Processing Guide and many
> others.  If it were of concern, people would have proven reports and
> data.  Thus, rotation of two disinfectants has no technical or scientific
> merit. Developed resistance and not being efficacious against an organism
> are two different things.
>
> Rotation of a disinfectant and a sporicide does have merit as the
> disinfectant may not have the ability to destroy spores.
>
> Art Vellutato, Jr.
> Veltek Associates, Inc.
> [log in to unmask]
>
> At 10:16 AM 12/5/2003 -0500, David Brodersen wrote:
> >Go to the Steris web site and they have technical reports discussing just
> >that topic which then supports the need for rotation between a high and
low
> >pH quat or same with high/low pH phenol (Note: do not rotate a quat and
> >phenol for they deactivate one another). Also to through in the use of
> >sporicidal for a week in between the rotation cycle.
> >
> >David Brodersen
> >Corporate Sterilization Microbiologist
> >
> >Arrow International Inc.
> >312 Commerce Place
> >Asheboro, NC 27203
> >Tel. (336) 498-4153
> >Fax. (336) 495-1642
> >
> >
> >
> >-----Original Message-----
> >From: Stewart, Ryan [mailto:[log in to unmask]]
> >Sent: Thursday, December 04, 2003 11:51 AM
> >To: [log in to unmask]
> >Subject: [PMFLIST] Resistant Organisms as a Result of Disinfectant /
> >Sporicidal Agen ts
> >
> >
> >Greetings list,
> >
> >Do anyone know of publications that sufficiently demonstrate
environmental
> >organisms can become "resistant" due to treatment with disinfectant /
> >sporicidal agents (i.e. LpH, Vesephene, TBQ, etc. / XSpore, SporKlenz,
etc.)
> >as a result of use?
> >
> >If such publications exist could you please provide references or links
if
> >possible.  Thanks!
> >
> >Thanks
> >rs
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> Please take a second to visit our sponsors' web sites and say thank you
for their support of this service.
> AAI - http://www.aaiintl.com/Micro.htm
> Accugenix - http://www.accugenix.com/
> Becton Dickinson Microbiology Systems - http://www.bd.com/industrial
> Microcheck - http://www.microcheck.com/
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> Microbial ID, Inc. - http://www.microbialid.com/
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> MIDI Labs, Inc. - http://www.midilabs.com/
> Millipore - http://www.millipore.com/
> NovaTek International - http://www.ntint.com
> Raven Biological Labs - http://www.ravenlabs.com
> Veltek Associates, Inc - http://www.sterile.com

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The PMFList (http://microbiol.org/PMFList_info.htm) is operated from
The Microbiology Network (http://microbiol.org) and supported by
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the scientific community.

Please take a second to visit our sponsors' web sites and say thank you for their support of this service.
AAI - http://www.aaiintl.com/Micro.htm
Accugenix - http://www.accugenix.com/
Becton Dickinson Microbiology Systems - http://www.bd.com/industrial
Microcheck - http://www.microcheck.com/
MIDI, Inc. - http://www.midi-inc.com/
Microbial ID, Inc. - http://www.microbialid.com/
MicroTest World Class Services - http://www.microtestlabs.com/
MIDI Labs, Inc. - http://www.midilabs.com/
Millipore - http://www.millipore.com/
NovaTek International - http://www.ntint.com
Raven Biological Labs - http://www.ravenlabs.com
Veltek Associates, Inc - http://www.sterile.com

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