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December 2003

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Subject:
From:
"Art Vellutato, Jr." <[log in to unmask]>
Reply To:
The Pharmaceutical Microbiology Forum Email List <[log in to unmask]>
Date:
Fri, 5 Dec 2003 14:46:20 -0500
Content-Type:
text/plain
Parts/Attachments:
text/plain (125 lines)
David,

There is no conclusive data published in the industry at levels noticed in
controlled environments and to support that an organism may become
resistant to a disinfecting agent. It is theoretical and should be excluded
from consideration. In fact, most regulatory agencies have not included in
their documentation or recommendations that two disinfectant should be
rotated to combat the possible building of a resistance to one or the
other.  This includes the new FDA Aseptic Processing Guide and many
others.  If it were of concern, people would have proven reports and
data.  Thus, rotation of two disinfectants has no technical or scientific
merit. Developed resistance and not being efficacious against an organism
are two different things.

Rotation of a disinfectant and a sporicide does have merit as the
disinfectant may not have the ability to destroy spores.

Art Vellutato, Jr.
Veltek Associates, Inc.
[log in to unmask]

At 10:16 AM 12/5/2003 -0500, David Brodersen wrote:
>Go to the Steris web site and they have technical reports discussing just
>that topic which then supports the need for rotation between a high and low
>pH quat or same with high/low pH phenol (Note: do not rotate a quat and
>phenol for they deactivate one another). Also to through in the use of
>sporicidal for a week in between the rotation cycle.
>
>David Brodersen
>Corporate Sterilization Microbiologist
>
>Arrow International Inc.
>312 Commerce Place
>Asheboro, NC 27203
>Tel. (336) 498-4153
>Fax. (336) 495-1642
>
>
>
>-----Original Message-----
>From: Stewart, Ryan [mailto:[log in to unmask]]
>Sent: Thursday, December 04, 2003 11:51 AM
>To: [log in to unmask]
>Subject: [PMFLIST] Resistant Organisms as a Result of Disinfectant /
>Sporicidal Agen ts
>
>
>Greetings list,
>
>Do anyone know of publications that sufficiently demonstrate environmental
>organisms can become "resistant" due to treatment with disinfectant /
>sporicidal agents (i.e. LpH, Vesephene, TBQ, etc. / XSpore, SporKlenz, etc.)
>as a result of use?
>
>If such publications exist could you please provide references or links if
>possible.  Thanks!
>
>Thanks
>rs
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>Veltek Associates, Inc - http://www.sterile.com

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The PMFList (http://microbiol.org/PMFList_info.htm) is operated from
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Please take a second to visit our sponsors' web sites and say thank you for their support of this service.
AAI - http://www.aaiintl.com/Micro.htm
Accugenix - http://www.accugenix.com/
Becton Dickinson Microbiology Systems - http://www.bd.com/industrial
Microcheck - http://www.microcheck.com/
MIDI, Inc. - http://www.midi-inc.com/
Microbial ID, Inc. - http://www.microbialid.com/
MicroTest World Class Services - http://www.microtestlabs.com/
MIDI Labs, Inc. - http://www.midilabs.com/
Millipore - http://www.millipore.com/
NovaTek International - http://www.ntint.com
Raven Biological Labs - http://www.ravenlabs.com
Veltek Associates, Inc - http://www.sterile.com

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