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December 2003

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Subject:
From:
"Art Vellutato, Jr." <[log in to unmask]>
Reply To:
The Pharmaceutical Microbiology Forum Email List <[log in to unmask]>
Date:
Tue, 9 Dec 2003 07:10:01 -0500
Content-Type:
text/plain
Parts/Attachments:
text/plain (264 lines)
One thing that has also always confused me is that if a firm routinely uses 
a sporicide (say monthly), how does this organism that became resistant to 
the disinfectant like phenol or quats know to run for the highlands and 
hide?  I find it amazing that the organism can make it though this type of 
scenario let alone just stay alive in the clean room.

Art Vellutato, Jr.
V.P. Technical Support Operations
Veltek Associates, Inc.
15 Lee Boulevard
Malvern, PA 19355
Tel: (610) 644-8335 X 110
Fax: (610) 644-8336
http://www.sterile.com

At 04:26 PM 12/8/2003 -0500, Daniel L. Prince wrote:
>I also agree with Art with respect to the control on hard surfaces of
>vegetative organisms with typical concentrations recommended by the
>manufacturers for the contact times specified by the manufacturers. An
>organism which is physically damaged and/or destroyed can not repair or
>regenerate itself like a starfish.
>Sincerely,
>
>Daniel Prince, Ph.D.
>Gibraltar Laboratories, Inc.
>122 Fairfield Road
>Fairfield NJ 07004-2401
>973-227-6882 x519
>www.gibraltarlabsinc.com
>----- Original Message -----
>From: "Bob Friedel" <[log in to unmask]>
>To: <[log in to unmask]>
>Sent: Friday, December 05, 2003 9:29 PM
>Subject: Re: [PMFLIST] Resistant Organisms as a Result of Disinfectant / S
>poricidal Agen ts
>
>
> > Agree with Art.
> >
> > Bob Friedel
> > [log in to unmask]
> >
> > ----- Original Message -----
> > From: "Art Vellutato, Jr." <[log in to unmask]>
> > To: <[log in to unmask]>
> > Sent: Friday, December 05, 2003 2:46 PM
> > Subject: Re: [PMFLIST] Resistant Organisms as a Result of Disinfectant / S
> > poricidal Agen ts
> >
> >
> > > David,
> > >
> > > There is no conclusive data published in the industry at levels noticed
>in
> > > controlled environments and to support that an organism may become
> > > resistant to a disinfecting agent. It is theoretical and should be
> > excluded
> > > from consideration. In fact, most regulatory agencies have not included
>in
> > > their documentation or recommendations that two disinfectant should be
> > > rotated to combat the possible building of a resistance to one or the
> > > other.  This includes the new FDA Aseptic Processing Guide and many
> > > others.  If it were of concern, people would have proven reports and
> > > data.  Thus, rotation of two disinfectants has no technical or
>scientific
> > > merit. Developed resistance and not being efficacious against an
>organism
> > > are two different things.
> > >
> > > Rotation of a disinfectant and a sporicide does have merit as the
> > > disinfectant may not have the ability to destroy spores.
> > >
> > > Art Vellutato, Jr.
> > > Veltek Associates, Inc.
> > > [log in to unmask]
> > >
> > > At 10:16 AM 12/5/2003 -0500, David Brodersen wrote:
> > > >Go to the Steris web site and they have technical reports discussing
>just
> > > >that topic which then supports the need for rotation between a high and
> > low
> > > >pH quat or same with high/low pH phenol (Note: do not rotate a quat and
> > > >phenol for they deactivate one another). Also to through in the use of
> > > >sporicidal for a week in between the rotation cycle.
> > > >
> > > >David Brodersen
> > > >Corporate Sterilization Microbiologist
> > > >
> > > >Arrow International Inc.
> > > >312 Commerce Place
> > > >Asheboro, NC 27203
> > > >Tel. (336) 498-4153
> > > >Fax. (336) 495-1642
> > > >
> > > >
> > > >
> > > >-----Original Message-----
> > > >From: Stewart, Ryan [mailto:[log in to unmask]]
> > > >Sent: Thursday, December 04, 2003 11:51 AM
> > > >To: [log in to unmask]
> > > >Subject: [PMFLIST] Resistant Organisms as a Result of Disinfectant /
> > > >Sporicidal Agen ts
> > > >
> > > >
> > > >Greetings list,
> > > >
> > > >Do anyone know of publications that sufficiently demonstrate
> > environmental
> > > >organisms can become "resistant" due to treatment with disinfectant /
> > > >sporicidal agents (i.e. LpH, Vesephene, TBQ, etc. / XSpore, SporKlenz,
> > etc.)
> > > >as a result of use?
> > > >
> > > >If such publications exist could you please provide references or links
> > if
> > > >possible.  Thanks!
> > > >
> > > >Thanks
> > > >rs
> > > >This message is intended only for the individual or entity to which it
>is
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> > to
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>the
> > > >original message.
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> > MIDI,
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> > > >Millipore - http://www.millipore.com/ NovaTek International -
> > > >http://www.ntint.com Raven Biological Labs - http://www.ravenlabs.com
> > Veltek
> > > >Associates, Inc - http://www.sterile.com
> > > >
> > > >------------------
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> > > >Accugenix - http://www.accugenix.com/
> > > >Becton Dickinson Microbiology Systems - http://www.bd.com/industrial
> > > >Microcheck - http://www.microcheck.com/
> > > >MIDI, Inc. - http://www.midi-inc.com/
> > > >Microbial ID, Inc. - http://www.microbialid.com/
> > > >MicroTest World Class Services - http://www.microtestlabs.com/
> > > >MIDI Labs, Inc. - http://www.midilabs.com/
> > > >Millipore - http://www.millipore.com/
> > > >NovaTek International - http://www.ntint.com
> > > >Raven Biological Labs - http://www.ravenlabs.com
> > > >Veltek Associates, Inc - http://www.sterile.com
> > >
> > > ------------------
> > > The PMFList (http://microbiol.org/PMFList_info.htm) is operated from
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> > > the scientific community.
> > >
> > > Please take a second to visit our sponsors' web sites and say thank you
> > for their support of this service.
> > > AAI - http://www.aaiintl.com/Micro.htm
> > > Accugenix - http://www.accugenix.com/
> > > Becton Dickinson Microbiology Systems - http://www.bd.com/industrial
> > > Microcheck - http://www.microcheck.com/
> > > MIDI, Inc. - http://www.midi-inc.com/
> > > Microbial ID, Inc. - http://www.microbialid.com/
> > > MicroTest World Class Services - http://www.microtestlabs.com/
> > > MIDI Labs, Inc. - http://www.midilabs.com/
> > > Millipore - http://www.millipore.com/
> > > NovaTek International - http://www.ntint.com
> > > Raven Biological Labs - http://www.ravenlabs.com
> > > Veltek Associates, Inc - http://www.sterile.com
> >
> > ------------------
> > The PMFList (http://microbiol.org/PMFList_info.htm) is operated from
> > The Microbiology Network (http://microbiol.org) and supported by
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> > the scientific community.
> >
> > Please take a second to visit our sponsors' web sites and say thank you
>for their support of this service.
> > AAI - http://www.aaiintl.com/Micro.htm
> > Accugenix - http://www.accugenix.com/
> > Becton Dickinson Microbiology Systems - http://www.bd.com/industrial
> > Microcheck - http://www.microcheck.com/
> > MIDI, Inc. - http://www.midi-inc.com/
> > Microbial ID, Inc. - http://www.microbialid.com/
> > MicroTest World Class Services - http://www.microtestlabs.com/
> > MIDI Labs, Inc. - http://www.midilabs.com/
> > Millipore - http://www.millipore.com/
> > NovaTek International - http://www.ntint.com
> > Raven Biological Labs - http://www.ravenlabs.com
> > Veltek Associates, Inc - http://www.sterile.com
> >
>
>------------------
>The PMFList (http://microbiol.org/PMFList_info.htm) is operated from
>The Microbiology Network (http://microbiol.org) and supported by
>our sponsors (http://microbiol.org/sponsor.htm) as a service to
>the scientific community.
>
>Please take a second to visit our sponsors' web sites and say thank you 
>for their support of this service.
>AAI - http://www.aaiintl.com/Micro.htm
>Accugenix - http://www.accugenix.com/
>Becton Dickinson Microbiology Systems - http://www.bd.com/industrial
>Microcheck - http://www.microcheck.com/
>MIDI, Inc. - http://www.midi-inc.com/
>Microbial ID, Inc. - http://www.microbialid.com/
>MicroTest World Class Services - http://www.microtestlabs.com/
>MIDI Labs, Inc. - http://www.midilabs.com/
>Millipore - http://www.millipore.com/
>NovaTek International - http://www.ntint.com
>Raven Biological Labs - http://www.ravenlabs.com
>Veltek Associates, Inc - http://www.sterile.com

------------------
The PMFList (http://microbiol.org/PMFList_info.htm) is operated from
The Microbiology Network (http://microbiol.org) and supported by
our sponsors (http://microbiol.org/sponsor.htm) as a service to
the scientific community.

Please take a second to visit our sponsors' web sites and say thank you for their support of this service.
AAI - http://www.aaiintl.com/Micro.htm
Accugenix - http://www.accugenix.com/
Becton Dickinson Microbiology Systems - http://www.bd.com/industrial
Microcheck - http://www.microcheck.com/
MIDI, Inc. - http://www.midi-inc.com/
Microbial ID, Inc. - http://www.microbialid.com/
MicroTest World Class Services - http://www.microtestlabs.com/
MIDI Labs, Inc. - http://www.midilabs.com/
Millipore - http://www.millipore.com/
NovaTek International - http://www.ntint.com
Raven Biological Labs - http://www.ravenlabs.com
Veltek Associates, Inc - http://www.sterile.com

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