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October 2009

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From:
"Vagell, Michael" <[log in to unmask]>
Reply To:
The Pharmaceutical Microbiology Forum Email List <[log in to unmask]>
Date:
Wed, 14 Oct 2009 21:17:46 -0400
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You could also try a ball-mill type homogenizer to pulverize the tablets. The Mikro-dismembrator U from Sartorius Stedim Biotech would be well suited for this application.  

Best regards, 

Mike Vagell, Ph.D. 
Sartorius Stedim Biotech 

Application Specialist
Laboratory Technologies 
Phone +1.877.452.2345 ext. 8828 | Fax +1.631.254.5460
Mobile +1.631.418.4736 

www.sartorius-stedim.com 
turning science into solutions

-----Original Message-----
From: The Pharmaceutical Microbiology Forum Email List on behalf of Zankhana Bhatt
Sent: Wed 10/14/2009 2:24 PM
To: [log in to unmask]
Subject: Re: [PMFLIST] Tablets that can not be analysed
 
You can use a stomacher.

Zankhana Bhatt
Sr. Microbiologist
Thibiant International
Phone # 818-709-1345x214


-----Original Message-----
From: The Pharmaceutical Microbiology Forum Email List
[mailto:[log in to unmask]]On Behalf Of Jelena Peric
Sent: Tuesday, October 13, 2009 11:21 PM
To: [log in to unmask]
Subject: [PMFLIST] Tablets that can not be analysed


Dear all,
 
some time ago I asked how to examine tablets that can not dissolve or desintegrate in common diluents, even with elevated temperatures. Most of you said that I should try to use a mortel and a pestle, to turn my tablets into a dusty, pulverized form. I tried to do that, and it worked pretty well. Until now.
 
I have tablets that are SR tablets, with extended release. They do not dissolve/desintegrate (even after 24 h in buffered peptone water, at 45 deg.). I tried to crush them with the morter and pestle, but they are so hard that crushing is virtually impossible.
 
I presume that I have three options now:
- to do analysis of the micro-purity anyway - that would be a sort of "tablet - rinse" analysis
- to buy a sort of grinding device?
- forget the micro analysis - make the problem of dissolution as a risk analysis argument for omitting the microbial purity parameter out of product specification
 
Does anyone have any ideas? Advice? Same kind of problems?
 
Thank You in advance,
 
Jelena


      

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the scientific community.

Please take a second to visit our sponsors' web sites and say thank you for their support of this service.

Accugenix - http://www.accugenix.com

American Type Culture Collection - http://www.atcc.org

Applied Biosystems, MicroSeq Microbial ID System - http://www.microseq.com/

BD Diagnostic Systems - http://www.bd.com/ds/

Biolog - http://www.biolog.com

Biomerieux - http://industry.biomerieux-usa.com

EMD Chemicals - http://www.emdchemicals.com

MicroBioLogics, Inc. - http://www.microbiologics.com

Millipore - http://www.millipore.com

MODA Technology Partners - http://www.modatp.com

Pall - http://www.pall.com

NovaTek International - http://www.ntint.com

Rapid Micro Biosystems - http://www.rapidmicrobio.com  (formerly GPS)

Raven Biological Labs - http://www.ravenlabs.com

Veltek Associates, Inc - http://www.sterile.com

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the scientific community.

Please take a second to visit our sponsors' web sites and say thank you for their support of this service.

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Applied Biosystems, MicroSeq Microbial ID System - http://www.microseq.com/

BD Diagnostic Systems - http://www.bd.com/ds/

Biolog - http://www.biolog.com

Biomerieux - http://industry.biomerieux-usa.com

EMD Chemicals - http://www.emdchemicals.com

MicroBioLogics, Inc. - http://www.microbiologics.com

Millipore - http://www.millipore.com

MODA Technology Partners - http://www.modatp.com

Pall - http://www.pall.com

NovaTek International - http://www.ntint.com

Rapid Micro Biosystems - http://www.rapidmicrobio.com  (formerly GPS)

Raven Biological Labs - http://www.ravenlabs.com

Veltek Associates, Inc - http://www.sterile.com

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The nature of this service is to provide a medium for communication.  The specific statements and endorsements of individuals participating in the discussions are not necessarily those of The Microbiology Network, Inc., the PMF, or the sponsors of the list.


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