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May 2011

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Subject:
From:
Jan Guillemette <[log in to unmask]>
Reply To:
The Pharmaceutical Microbiology Forum Email List <[log in to unmask]>
Date:
Tue, 17 May 2011 09:17:16 -0400
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IU's measure the potency of a drug, not its mass or weight.  I do not believe you can convert IU to micrograms or milligrams

-----Original Message-----
From: The Pharmaceutical Microbiology Forum Email List [mailto:[log in to unmask]] On Behalf Of BERES Carolyn
Sent: Monday, May 16, 2011 9:40 AM
To: [log in to unmask]
Subject: [PMFLIST] Converting I.U. to micrograms for Gentamicin Sulfate

Hello!

I'm looking for some information regarding conversion of International Units per milligram to micrograms per milligram for Gentamicin Sulfate.

The Certificate of Analysis for drug powder I'm working with states the potency in I.U./mg however the USP monograph (and nearly all documentation I've found) states potency in micrograms/mg.  The only information I've found that lists the potency for Gentamicin in I.U/mg is the WHO Pharmacopoeia Library Monograph.

USP monograph: minimum potency = >590 micrograms/mg
WHO monograph: minimum potency = >590 International Units/mg

I'm interested in determining potency in micrograms/mg.  Since the minimum requirements for potency appear to be the same (with the exception to units), can I assume that I.U. is equivalent to micrograms?


Thank you in advance for your advice!


Cari


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The PMFList (http://microbiol.org/PMFList_info.htm) is operated from
The Microbiology Network (http://microbiol.org) and supported by
our sponsors (http://microbiol.org/sponsor.htm) as a service to
the scientific community.

Please take a second to visit our sponsors' web sites and say thank you for their support of this service.

Accugenix - http://www.accugenix.com

American Type Culture Collection - http://www.atcc.org

BD Diagnostic Systems - http://www.bd.com/ds/

Biolog - http://www.biolog.com

Biomerieux - http://industry.biomerieux-usa.com

Biotest - http://www.BiotestUSA.com/micro

MicroBioLogics, Inc. - http://www.microbiologics.com

MODA Technology Partners: now a LONZA company http://lonza.com/moda

Pall - http://www.pall.com

NovaTek International - http://www.ntint.com

Rapid Micro Biosystems - http://www.rapidmicrobio.com  (formerly GPS)

Veltek Associates, Inc - http://www.sterile.com

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The nature of this service is to provide a medium for communication.  The specific statements and endorsements of individuals participating in the discussions are not necessarily those of The Microbiology Network, Inc., the PMF, or the sponsors of the list.

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