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February 2016

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Subject:
From:
"Dr. Yogesh Vyas" <[log in to unmask]>
Reply To:
The Pharmaceutical Microbiology Forum Email List <[log in to unmask]>
Date:
Sun, 21 Feb 2016 16:02:03 +0530
Content-Type:
text/plain
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text/plain (95 lines)
Dear vanina
You can try 2% soyalecithin and 0.5% poly sorbate 80 at 1:100 dilution.
You will get. Desired results.
You can call on my no 0091-9949411776
On 21-Feb-2016 10:36 am, "Vanina" <[log in to unmask]> wrote:

> Dear forum members:
> We are developing microbiological validation of atorvastatin drugs. The
> atorvastatin has antimicrobial properties and it has poor solubility in
> watter.
> Our laboratory follows the requeriments of USP <61> and USP <62>.
> The firts method we used was with soy bean - casein digest broth with 5%
> tween 80 and 0,5% soy lecithin but we haven't an appropriate percentage of
> microbial recovery.
> In orden to improve microbial recovery we changed the mentioned protocol
> for the following: soy bean- casein digest broth with 8% tween 80 and 0,5%
> lecithin. Howevwr, the percentage of microbial recovery was not increased
> significantly.
> In both cases, the neutralization method employed does not impair the
> viability of microorganims.
> Anyone have any idea to help me?
> Kind regards
>
>
> Dra Vanina Perez
> Medicines Production Division
> Microbiology Quality Control Laboratory
> National of University of La Plata
> Argentine
>
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The PMFList (http://microbiologynetwork.com/pmflist.asp) is operated from
The Microbiology Network (http://microbiologynetwork.com) and supported by
our sponsors as a service to the scientific community.

Please take a second to visit our sponsors' web sites and say thank you for their support of this service.

Accuratus Lab Services http://www.accuratuslabs.com/

Associates of Cape Cod, Inc. - http://www.acciusa.com/

Nelson Labs - http://www.nelsonlabs.com

BD Diagnostic Systems - http://www.bd.com/ds/

Biolog - http://www.biolog.com

Analytical Research Labs - http://arlok.com/

Charles River-Endosafe and Accugenix - http://www.criver.com/emd

Microbiologics, Inc. - http://www.microbiologics.com

Steris - http://www.sterislifesciences.com/

Veltek Associates, Inc - http://www.sterile.com

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The nature of this service is to provide a medium for communication.  The specific statements and endorsements of individuals participating in the discussions are not necessarily those of The Microbiology Network, Inc., the PMF, or the sponsors of the list.

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