Holly,

Warren is absolutely correct, you need to perform the AET (if you are
international, the USP and EP together in one test) on every new formulation
and can never suppose that a similar product will perform the same.
Claude Anger

        -----Original Message-----
        From:   Casey, Warren M [SMTP:[log in to unmask]]
        Sent:   Monday, July 19, 1999 5:39 AM
        To:     [log in to unmask]
        Subject:        Re: [PMFLIST] Matrixing Samples for Antimicrobial
Effectiveness

        Holly,

        We perform testing on each product.  We have found that even very
small
        changes in a products formulation can have a profound effect on
        antimicrobial efficacy.

        Warren

        > -----Original Message-----
        > From: Holly Erickson [SMTP:[log in to unmask]]
        > Sent: Friday, July 16, 1999 6:31 PM
        > To:   [log in to unmask]
        > Subject:      [PMFLIST] Matrixing Samples for Antimicrobial
Effectivness
        >
        >     Colleagues,
        >     For those of you performing Antimicrobial Effectiveness
Testing, I'd
        > like to
        >     take a poll:
        >
        >     Do you perform AET on each product?
        >     Or do you allow the results for one product to represent other
        > products with
        >     equivalent matrices?
        >     Have you had any discussion with FDA on this issue?
        >
        >     Any info on the subject would be appreciated!
        >
        >     Holly Erickson
        >     Chiron Corporation
        >
        >
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