Hi all! I have a question for the group about cascading batches: Suppose you wanted to fill consecutive batches (i.e., no CIP/SIP between sublots..just flush the line with the next batch prior to filling). Does anyone routinely do this, and if so, do you release all the sublots after all the sterility tests are in, or do you release each sublot as each test comes off. Also, when would you perform filter integrity tests. I would like to know if there is an industry standard with this practice. Thanks. Michael Dr. Michael J. Miller Director, Biological and Sterilization Sciences Bausch & Lomb [log in to unmask] ------------------ The PMFList (http://microbiol.org/PMFList_info.htm) is operated from The Microbiology Network (http://microbiol.org) and supported by our sponsors (http://microbiol.org/sponsor.htm) as a service to the scientific community.